The primary focus of our research is to understand the genetic and molecular mechanisms of intracellular bacterial pathogenesis.
One major focus is to understand how the host recognizes and responds to intracellular bacterial pathogens. We have shown that cytosolic recognition of some bacteria leads to Type I Interferon signaling and Inflammasome activation. We take both a genetic and biochemical approach to understand the molecular mechanisms involved in host recognition pathways leading to inflammation and pathogen evasion mechanisms.
