Re-classification of COPD into sub-entities with unique genetic/cellular/molecular/physiologic/radiological and clinical cascades.
Understanding phenotypes and mechanisms producing systemic vascular disease in patients with COPD
Developing bio markers, including novel quantitative CT parameters, for defining pulmonary vascular disease in patients with COPD
Understanding the benefits of non-invasive ventilation in patients with acute exacerbations of COPD
Clarifying methodological issues in physiologic outcome assessment in lung disease, including determination of validity, precision and responsiveness of various exercise tools.