The focus of his research is host-pathogen interactions, emphasizing Salmonella and Coccidioides immitis. Most recently, his research has focused on the role of innate immunity in resistance to Salmonella infections, and on the genetic basis of resistance to coccidioidomycosis, using murine infections as model systems. Resistance genes are being mapped in mice, and the interplay between these genes and cytokine responses to infection is under investigation. Dr. Fierer is a Fellow of the Infectious Diseases Society of America, AAAS, and the American Academy of Microbiology.