Correlation of protein structure with function; protein-receptor interactions, protein-protein interactions, conformation of proteins and peptides, immune recognition of proteins by antibodies and by T cells; manipulation of the immune response, antigen presentation; design of synthetic peptide vaccines to neurotoxins and viral pathogens, peptide synthesis.
Major research activities include the following: Antibody and T-cell recognition of proteins at the submolecular level and genetic control of the immune response; design and synthesis of anti-viral peptide vaccines; development of peptide vaccines against neurotoxins; mechanism of antigen presentation to the T cell; mechanism of T-B and T-T cell collaboration, dissection and synthesis of active sites of neurotoxins; molecular and cellular recognition involved in autoimmune responses; development of sensitive immunodiagnostic tests for early diagnosis of cancer.
