His graduate study focused on human genetics and mouse modeling of cohesinopathies, and his postdoctoral work on studying function, regulation, and evolution of long (MALAT1 and NEAT1) and small (piRNAs) non-coding RNAs (ncRNAs). He maintains active research interests in RNA-based disease biology, cancer biology, and biomarker discovery using genomic approaches. In particular, his research program at University of Rochester focuses on studying molecular and cellular functions of ncRNAs during tumoriogenesis, and developing novel NGS-based methodologies for efficient circulating tumor DNA (ctDNA) detection and nucleotide-level mapping of disease-associated chromosomal rearrangements.