Dr. Mesfin is interested in clinical outcomes research including following spine tumor surgery and basic science degenerative disc disease research. He has received grant funding for his research. He has more than 100 published articles and more than 165 national and international presentations. He is a member of the Cervical Spine Research Society, North American Spine Society, and candidate member of the Scoliosis Research Society. He is also a member of the American Academy of Orthopaedic Surgeons, J. Robert Gladden Society, National Medical Association and the American Orthopaedic Association's Emerging Leader Program. Dr. Mesfin has given numerous national and international presentations, authored many spine related publications in peer-reviewed journals and has won awards for his research.