Dr. Brima uses high-density electrophysiology and Magnetic Resonance Imaging to investigate neural correlates in rare genetic neurodevelopmental diseases such as Batten disease and Rett syndrome. The aim of her current study is to identify disease markers specific to these diseases. Her long-term goal is to develop objective quantitative measures of brain function (i.e. neuromarkers) that can be tracked in a noninvasive and unbiased manner. These neuromarkes could serve as ideal disease markers that can validate clinical trial outcome measures and track disease progress especially in populations where conventional evaluation is challenging.
