The focus of my laboratory is on integrative physiology, and in particular on understanding the molecular mechanisms whereby bioenergetic responses influence metabolic plasticity, survival, and behavior in a whole organism. Our goal is to develop a deeper understanding of how these cell physiologic processes are integrated to mediate the environmental sensitivity and functional output exhibited by live animals. Recent focuses have been on mitochondrial ion flux, proteostasis and trans-organelle signaling pathways that regulate hypoxic sensitivity. We believe that combining physiology and genetics provides synergistic value in deciphering mechanisms whereby cells communicate information in their native context. My unique, diverse background has helped my lab to harness the power of new tools such as CRISPR-Cas9 genome editing while translating our findings from the genetic model organism C. elegans to mammalian models such as mice. And collaboration being the heart-and-soul of science, we are pleased to be able to interact with our colleagues in a collegial and inclusive atmosphere where everyone's unique contributions to the team are valued.
