The major objective of my research program is to understand the interaction between genetic and environmental risk and protective factors for obesity and diabetes in Yup'ik Eskimos. Identification of gene-environment interactions that influence energy balance should lead to a better understanding of the pathophysiological mechanisms contributing to body fat development and is also an important aspect of public health intervention. Our studies are designed and implemented within a community-based participatory research framework that involves extensive interactions with community leaders and health corporation representatives.
