My research is centered on calcific aortic stenosis, including several clinical and translational projects related to biomarker discovery, risk prediction, and elucidating pathophysiology to identify adjunctive interventions to improve patient-centered outcomes. Our group uses various imaging techniques and a biobank of specimens to perform biomarker discovery and understand the pathobiology of aortic stenosis and the effects of pressure overload on the left ventricle and pulmonary vasculature. We have a particular interest in how diabetes affects these processes and aim to identify novel targets for adjunctive medical therapy to improve clinical outcomes in patients with aortic stenosis. Novel rehabilitation strategies targeting frailty are also an area of interest.
