My research is focused on understanding the immunopathogenesis of HIV infection. I have been involved in clinical trials of a variety of immune therapies for HIV infection since 1994. I have also pursued laboratory-based investigations of HIV immunopathogenesis for the past 20 years particularly studies of acute HIV infection, virus tropism, immune reconstitution, cardiovascular disease, and HIV infection in women. I have specific expertise in studies of HIV pathogenesis in lymphoid tissues, where the majority of HIV replication and CD4+ T cell destruction occurs. I currently have R01 bridge funding to investigate the mechanisms underlying HIV’s evasion of cytotoxic T cell responses in lymphoid tissues, and am co-PI of a R01 investigating the impact of exercise on endothelial dysfunction in HIV-infected individuals.
