The Kazak lab combines mouse genetics, mass spectrometry, molecular and cell biology, biochemistry and bioenergetics to study the molecular control of mammalian energy metabolism. Our efforts are concentrated on the molecules and metabolic pathways that control mitochondrial energetics in adipocytes and cancer cells. We have generated novel genetically-engineered mouse models to accurately study cellular metabolism, in vivo. In the case of adipose tissue, we systematically examine mechanisms supporting adipocyte energy expenditure, which has tremendous promise for combating obesity. In the case of cancer, we are leveraging our expertise of mitochondrial biology and cellular energetics to explore novel metabolic pathways that are critical for tumorigenesis.
