Research in the last decades clearly demonstrated that inter-organ communication is of great importance in the pathophysiology of many diseases. It is now recognized that skeletal muscles secrete cytokines named myokines that can impact on the function of distant tissues both positively and negatively.
The research conducted in Dr. Aguer's laboratory focusses on how factors secreted by skeletal muscles during contraction impact cardiometabolic health with a focus on chronic diseases linked to increased inflammation (insulin resistance, type 2 diabetes, depression, etc.). The scope of her research is aimed at determining the impact of alteration in the muscle secretome, which may be induced by exercise, important chronic diseases linked to increased inflammation and environmental pollutants.
