Postdoctoral research position to conduct independent neuroscience research in Dr. Daniel A. Peterson’s laboratory in regenerative medicine in collaboration with Dr. Grace E. Stutzmann’s laboratory researching Alzheimer’s disease. The research focus will be related to in vivo neuronal reprogramming and the morphological and functional integration of newly reprogrammed neurons on a background of Alzheimer’s disease. This position will directly support preclinical studies to develop new therapies.
Essential Duties & Responsibilities
Primary responsibilities are to independently conduct morphological and functional imaging experiments in brain slice and in vivo preparations in rodents, and in iPSCs from human samples and other cultured cell models. Imaging will be conducted by resonance scanning confocal and multiphoton microscopy and light sheet microscopy with quantitative analysis using stereology and artificial intelligence. Functional analysis will include whole cell patch and field potential electrophysiology and calcium imaging modalities in brain slice and cell culture preparations. Duties include rodent surgical procedures, stereotaxic brain surgery, and histological sample preparation, as well as data analysis, manuscript/grant preparation and writing associated with project. The postdoctoral fellow will be responsible for mentoring/teaching techniques to qualified students and technicians.
Required Education & Experience
- PhD in neuroscience or stem cell-related discipline.
- Demonstrated productivity and strong publication record.
- Must be able to achieve a background check clearance
Required Knowledge Skills & Abilities
- Demonstrated expertise in rodent surgical procedures including stereotaxic surgery and transcardial perfusion
- Demonstrated expertise in histological sample preparation for multiple fluorescence labeling
- Demonstrated expertise in confocal microscopy
- Demonstrated experience in image analysis and stereology
- Demonstrated expertise in electrophysiological recording using whole cell patch clamp and field potentials in brain slices
- Experience in statistical analysis
- Excellent organizational and planning skills
- Knowledge about computer applications such as Word, Excel and PowerPoint
- Excellent English reading, writing and verbal communication skills
- Ability to collect and analyze data
- Ability to work independently and as part of a team
- Demonstrated project management skills, including ability to set priorities and excellent time management skills
- Ability to work productively with diverse populations; show respect and sensitivity for cultural differences
Typical Physical Demands & Working Conditions
Selected candidate must have the mental and physical capabilities to perform the essential functions of the position with or without reasonable accommodations.